IRed Wine Headache phenomena experienced by so many people that it has its very own Wikipedia page could be explained by health professionals, and whether or not casual drinkers should be concerned.

Wine-related headaches are actually one of the center’s topmost cases but knowledge is limited.

The type of oak casket used in fermentation may play a role, but it’s not clear which oak is worse.  Some who experience wine-related headaches wonder if they are actually allergic to sulfites. This is rare, and there are more sulfites in white wine, suggesting it isn’t that.

Wine drinkers could be suffering from dehydration, given that alcohol acts as a diuretic (this is true for all alcoholic drinks), which is the root of the problem for many. Another explanation may be a depletion of magnesium:  Alcohol is a major depleter of magnesium,  chronic headache sufferers seek out 400mg of magnesium supplements per day, and see if that doesn’t help.

There’s not much-published research on wine headaches: Teague unearthed a 1988 Lancet study, titled “Red Wine as a Cause of a Migraine,” where two groups of drinkers were asked to drink either red wine or a substitute (diluted vodka disguised as wine) to see if migraines came exclusively from one or the other. The participants chugged down 300 milliliters, around two glasses, and waited to see if they were affected.

The results, however, weren’t clear: some participants developed headaches, while others did not. One possible lead suggested that tyramine, a naturally occurring compound found in both food and wine, has previously been found to trigger migraine headaches but the amount of tyramine in both red and white wine is less than 2 milligrams per meter.

Histamines naturally produced in most wines, another possible culprit. There is not much evidence for the theory.

But another expert explained why histamines could be an issue told Food & Wine that genetics could play a part in how you digest and metabolize wine. In the case of histamines, certain genetic dispositions (or medications) could mean you’re not metabolizing histamines effectively, which means that symptoms like facial flushing and headaches would be much more common after even just a few sips of wine.

But maybe the simplest explanation is the possibility that hears us out you may be hung over.

You should consider your case serious if you notice an immediate reaction to the first glass of wine you’ve tasted,  One drink of red wine can trigger a migraine if you’re sensitive to it, but one glass of red wine probably isn’t going to give you a hangover,

The bottom line:  Magnesium supplements may help if you’re experiencing a deficiency, but not if your levels are normal.

More research is needed to pinpoint the cause of wine-induced headaches, but identifying the issue may help you minimize it as much as possible: talk with your healthcare provider if you feel that histamines may be the issue, or if you experience a magnesium deficiency. And make sure you’re properly hydrated before enjoying a bottle with friends.